生化学講座

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講座員

研究業績（共著を除く）

2020年

Miyazaki T, Akasu R, Miyazaki A. Calpain proteolytic systems counteract endothelial cell adaptation to inflammatory environments. Inflamm Regen. 2020;40:5. (Invited review article)



2019年

Miyazaki T, Haraguchi S, Kim-Kaneyama JR, Miyazaki A. Endothelial calpain systems orchestrate myofibroblast differentiation during wound healing. FASEB J. 2019;33:2037-2046.

Miyazaki T, Miyazaki A. Impact of dysfunctional protein catabolism on macrophage cholesterol handling. Curr Med Chem. 2019;26:1631-1643.(Invited review article)

Miyauchi A, Kim-Kaneyama JR, Lei XF, Chang SH, Saito T, Haraguchi S, Miyazaki T, Miyazaki A. Alleviation of murine osteoarthritis by deletion of the focal adhesion mechanosensitive adapter, Hic-5. Sci Rep. 2019;9:15770.

宮崎章. 動脈硬化病変形成におけるマクロファージの役割. 別冊「医学のあゆみ」動脈硬化UPDATE. 2019.

宮崎 拓郎. マクロファージ動脈硬化原性を制御する細胞内プロテアーゼシステム. 糖尿病合併症. 2019;33:114-116.



2018年以前

Miyazaki T, Miyazaki A. Dysregulation of calpain proteolytic systems underlies degenerative vascular disorders. J Atheroscler Thromb. 2018;25:1-15. (Invited review article)

Omoto T, Kim-Kaneyama JR, Lei XF, Orimo A, Ohnishi K, Yoshihara K, Miyauchi A, Li S, Gao L, Umemoto T, Tanaka J, Nakahara K, Takeya M, Ishida F, Kudo SE, Haraguchi S, Miyazaki T, Miyazaki A. The impact of stromal Hic-5 on the tumorigenesis of colorectal cancer through lysyl oxidase induction and stromal remodeling. Oncogene. 2018;37:1205-1219.


Miyazaki T, Miyazaki A. Defective protein catabolism in atherosclerotic vascular inflammation. Front Cardiovasc Med. 2017;4:79.
[Frontier’s Research topic: New Trends in Vascular Inflammation Research: From Biology to Therapy] (Invited review article)

Miyazaki T, Miyazaki A. Emerging roles of calpain proteolytic systems in macrophage cholesterol handling. Cell Mol Life Sci. 2017;74:3011-3021. (Invited review article)
[Cell Mol Life Sci 74の表紙に採用]

Kigawa Y, Miyazaki T, Lei XF, Kim-Kaneyama JR, Miyazaki A. Functional heterogeneity of NADPH oxidases in atherosclerotic and aneurysmal diseases. J Atheroscler Thromb. 2017;24:1-13. (Invited review article)


Miyazaki T, Tonami K, Hata S, Aiuchi T, Ohnishi K, Lei XF, Kim-Kaneyama JR, Takeya M, Itabe H, Sorimachi H, Kurihara H, Miyazaki A. Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicing. J Clin Invest. 2016;126:3417-3432.
[JCI This MonthでEditorialとして特集;第21回日本血管生物医学会学術集会Young Investigator’s Award、第4回万有医学奨励賞優秀賞、循環器学研究振興基金「内田賞」受賞論文]

Lei XF, Fu W, Kim-Kaneyama JR, Omoto T, Miyazaki T, Li B, Miyazaki A. Hic-5 deficiency attenuates the activation of hepatic stellate cells and liver fibrosis through upregulation of Smad7 in mice. J Hepatol. 2016; 64:110-7.


Miyazaki T, Taketomi Y, Saito Y, Hosono T, Lei XF, Kim-Kaneyama JR, Arata S, Takahashi H, Murakami M, Miyazaki A. Calpastatin counteracts pathological angiogenesis by inhibiting suppressor of cytokine signaling 3 degradation in vascular endothelial cells. Circ Res. 2015;116:1170-1181.
[第47回日本動脈硬化学会学術集会優秀ポスター賞受賞]

Arita-Okubo S, Kim-Kaneyama JR, Lei XF, Fu WG, Ohnishi K, Takeya M, Miyauchi A, Honda H, Itabe H, Miyazaki T, Miyazaki A. Role of Hic-5 in the formation of microvilli-likestructures and themonocyte-endothelial interaction that accelerates atherosclerosis. Cardiovasc Res. 2015; 105: 361-371.
[日本動脈硬化学会第24回若手研究者奨励賞 優秀賞受賞論文]



Kigawa Y, Miyazaki T, Lei XF, Nakamachi T, Oguchi T, Kim-Kaneyama JR, Taniyama M, Tsunawaki S, Shioda S, Miyazaki A. NADPH oxidase deficiency exacerbates angiotensinII-induced abdominal aortic aneurysms in mice. Arterioscler Thromb Vasc Biol. 2014;34:2413-20.
[日本動脈硬化学会第23回若手研究者奨励賞 優秀賞受賞論文]

Lei XF, Kim-Kaneyama JR, Arita-Okubo S, Offermanns S, Itabe H, Miyazaki T, Miyazaki A. Identification of Hic-5 as a novel scaffold for the MKK4/p54 JNK pathwayin the development of abdominal aortic aneurysms. J Am Heart Assoc. 2014;3:e000747.



Miyazaki T, Koya T, Kigawa Y, Oguchi T, Lei XF, Kim-Kaneyama JR, Miyazaki A. Calpain and atherosclerosis. J Atheroscler Thromb. 2013;20:228-237. (Invited review article)

宮崎 拓郎, 黄川 恵慈, 小口 達敬, 宮崎 章. カルパインと動脈硬化症. 昭和大学薬学雑誌. 2013;4,27-35.

Kim-Kaneyama JR, Lei XF, Arita S, Miyauchi A, Miyazaki T, Miyazaki A. Hydrogen peroxide-inducible clone 5 (Hic-5) as a potential therapeutic target for vascular and other disorders. J Atheroscler Thromb. 2012;19:601-607. (Invited review article)



Koya T, Miyazaki T, Watanabe T, Shichiri M, Atsumi T, Kim-Kaneyama JR, Miyazaki A. Salusin-β accelerates inflammatory responses in vascular endothelial cells via NF-κB signaling in LDL receptor-deficient mice in vivo and HUVECs in vitro. Am J Physiol Heart Circ Physiol. 2012;303:H96-H105.
[Am J Physiol Heart Circul Physiol 303の表紙に採用]

Kim-Kaneyama JR, Miyauchi A, Lei XF, Arita S, Mino T, Takeda N, Kou K, Eto K, Yoshida T, Miyazaki T, Shioda S, Miyazaki A. Identification of Hic-5 as a novel regulatory factor for integrin αIIbβ3 activation and platelet aggregation in mice. J Thromb Haemost. 2012;10:1867-1874.



Miyazaki T, Taketomi Y, Takimoto M, Lei XF, Arita S, Kim-Kaneyama JR, Arata S, Ohata H, Ota H, Murakami M, Miyazaki A. m-Calpain induction in vascular endothelial cells on human and mouse atheromas and its roles in VE-cadherin disorganization and atherosclerosis.Circulation. 2011;124:2522-2532.
[同号Editorialで特集（Circulation. 2011;124:2480-2482.）; Most Read Articles in Atherosclerosis, published in Circulation and the Circulation subspecialty journalsとして2011年および2012に2年連続で選出；日本動脈硬化学会第20回若手研究者奨励賞 最優秀賞受賞論文]


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